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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/990

Title: Novel pathways induced by melatonin on leukocytes: possible pharmacological and inflammatory perspectives
Authors: Ghibelli, Lina
Radogna, Flavia
Keywords: melatonin
apoptosis
lipoxygenase
Issue Date: 6-Aug-2009
Abstract: Melatonin, in addition to its main role as regulator of circadian rhythms, has recently been shown to modulate immune functions by controlling the behaviour of leukocytes, which are indeed able to synthesize melatonin and possess the specific high affinity (1nM) plasma membrane receptors (MT1 and MT2). Great interest is receiving the ability of melatonin to contrast apoptosis, a well accepted fact whose mechanisms however are still quite controversial. In this study, we analyze the mechanisms involved in the anti-apoptotic effect of melatonin in normal and tumor leukocytes. We have shown that this effect is due to two different, cooperating mechanisms, involving two primary targets melatonin directly interacts with, i.e., MT1/MT2 receptors; and calmodulin, a known melatonin low affinity (63uM) target. Receptor engagement and calmodulin binding give rise to two independent signal transduction pathways, consisting of a canonical MT1/MT2 receptor mediated signal transduction (involving G ...
Description: 21. ciclo
URI: http://hdl.handle.net/2108/990
Appears in Collections:Tesi di dottorato in scienze matematiche e fisiche

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