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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/965

Title: Identificazione di co-attivatori trascrizionali e di geni bersaglio per i fattori di trascrizione tessuto-specifici Pax 8 e TTF-1
Authors: Novelli, Giuseppe
Provenzano, Claudia
Keywords: transcription
coactivator
Pax 8
retinoblastoma protein
thyroid
TTF-1
puberty
Issue Date: 31-Jul-2009
Abstract: The identity of each cell type is controlled mostly at the transcriptional level by unique combinations of transcription factors. The study of transcription factors regulating specific expression in differentiated cell culture systems allows the comprehension of the molecular mechanisms leading to cell differentiation and organogenesis. The transcription factors TTF-1 and Pax 8 play a pivotal role in thyroid follicular cells differentiation as well as thyroid differentiation marker genes transcriptional regulation. TTF-1 and Pax 8 cooperatively activate the expression of the thyroperoxidase (TPO) and thyroglobulin (Tg) genes involved in the synthesis of the thyroid hormones. Recently it has been shown that TTF-1 plays an important role in neuroendocrine cells of the hypothalamus, where it induces expression of the peptide luteinizing hormone-releasing hormone (LHRH) that regulates female sexual development in mammals. In this study we investigated two novel characteristics of these...
Description: 19. ciclo
URI: http://hdl.handle.net/2108/965
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