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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/937

Title: Regolazione epatica del segnale insulinico
Authors: Lauro, Renato
Capuani, Barbara
Keywords: insulino resistenza
segnale insulinico
recettore insulinico
tessuto epatico
elettroforesi bidimensionale
Issue Date: 29-Jul-2009
Abstract: In the western society and developing countries the incidence of insulin resistance, type-2 diabetes mellitus (T2DM) and augmented metabolic risk for cardiovascular disease and T2DM, are increasing exponentially. This raise is due mainly to an urbanized life style and to age of population. The shared feature of these related diseases is an impaired response to insulin target tissues, insulin resistance, and/or reduction of insulin secretion in pancreatic beta cells. Studies of these aspects are performed: in vitro, culture cell lines of fibroblasts/hepatocytes derived from insulin receptor knockout (IRKO) mice transformed by adenovirus SV40; ex vivo, in genetically modified animal (mouse) models for insulin receptor knockout (IRKO). It has been analyzed the differences in proteins expression profile and insulin signaling transmission in IRKO hepatocytes and IRKO mouse liver tissues compared with the wild type and heterozygous phenotypes. The aims of this study are to detect differences...
Description: 19.ciclo
URI: http://hdl.handle.net/2108/937
Appears in Collections:Tesi di dottorato in medicina

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