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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/927

Title: Alterazione funzionale dei canali ionici nel sistema nervoso centrale in un modello murino di sclerosi laterale amiotrofica
Authors: Zona, Cristina
Pieri, Massimo
Keywords: ASL
action potentials
motor neurons
sodium current
Issue Date: 14-Jul-2009
Abstract: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a substantial loss of motor neurons in the spinal cord, brainstem and motor cortex. The degeneration of motor neurons leads to skeletal muscle atrophy, paralysis and death. The mechanisms by which mutations in SOD1 lead to motor neuron degeneration remain unidentified. Several mechanisms have been suggested by which a mutation of SOD1 may lead to motor neuron toxicity and degeneration, including the formation of intracellular aggregates (Johnston et al., 2000), production of reactive oxidative species (Estevez et al., 1999), mitochondrial degeneration (Higgins et al., 2002), altered AMPA receptor permeability and subunit composition (Pieri et al., 2003; Spalloni et al., 2004), increase in intracellular Ca2+ concentration by Ca2+-permeable AMPA receptor channels (Van Den Bosch et al., 2000; Weiss et al., 2000) and protein nitration (Casoni et al., 2005). In the present work, the excitability of...
Description: 19.ciclo
URI: http://hdl.handle.net/2108/927
Appears in Collections:Tesi di dottorato in medicina

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