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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/926

Title: A new genetic element carrying the resistance determinant erm(TR) in Streptococcus pneumoniae
Authors: Pantosti, Annalisa
Camilli, Romina
Keywords: macrolide resistance
erm(A) subclass erm(TR)
genetic element
Issue Date: 14-Jul-2009
Abstract: The rapid development of macrolide resistance in Streptococcus pneumoniae, particularly over the last decade, is of major clinical concern. The two main resistance mechanisms of macrolide resistance in S. pneumoniae are target site modification mediated by erm(B) and efflux mediated by mef genes. Recently the presence of another methylase gene, erm(A) subclass erm(TR), has been reported in few S. pneumoniae clinical cases from different part of the world. The erm(TR) gene is common in Streptococcus pyogenes but rare in S. pneumoniae. Although erm(TR) has been demonstrated to be transferable from S. pyogenes to other Gram-positive species, the genetic element carrying this resistance determinant has not been identified. Recently, a clinical S. pneumoniae isolate (AP200) carrying erm(TR) has been obtained from a patient with meningitis in Italy. In this work we have analysed the erm(TR)-carrying genetic element in AP200. This strain has been phenotypically and genotypically ch...
Description: 19.ciclo
URI: http://hdl.handle.net/2108/926
Appears in Collections:Tesi di dottorato in medicina

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