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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/923

Title: New physiological roles of glautathione transferases
Authors: Ricci, Giorgio
Dawood, Kutayba Farhan
Keywords: glutathione S-transferase (GST)
Issue Date: 13-Jul-2009
Abstract: Glutathione transferases (GSTs) are enzymes able to conjugate GSH to a lot of toxic compounds thereby favoring their excretion. Recently, other protective roles of these enzymes have been discovered. In particular, it has been observed that a peculiar and strong interaction exists between some mammalian GSTs and an endogenous carrier of nitric oxide, the dinitrosyl-diglutathionyl iron complex (DNDGIC). This iron complex is a paramagnetic molecule with a characteristic EPR spectrum centered at g = 2.03, that is spontaneously formed when NO enters the cell. This complex is a strong irreversible inhibitor of glutathione reductase. The present work explores the possible role of GSTs like a protection system against DNDGIC. Actually, mammalian GSTs bind DNDGIC with extraordinary affinity (KD = 10-9-10-10 M). When rat hepatocytes are incubated in the presence of GSNO, a natural source of NO, a rapid formation of 0.1 - 0.2 mM intracellular DNDGIC has been observed. This concentration would b...
Description: 21. ciclo
URI: http://hdl.handle.net/2108/923
Appears in Collections:Tesi di dottorato in scienze matematiche e fisiche

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