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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/909

Title: Ruolo della chinasi PIM1 in risposta allo stress ribosomale
Authors: Loreni, Fabrizio
Iadevaia, Valentina
Keywords: PIM1
stress ribosomale
ribosomi
Issue Date: 27-May-2009
Abstract: PIM1 is an oncogenic serine/threonine kinase mainly expressed in hematopoietic cells. Expression of PIM1 is regulated by a variety of growth factors and cytokines from transcriptional to post-translational level. Together with the other two members of the family (PIM2 and PIM3), PIM1 plays a role in hematopoietic cell growth and survival. By studying the molecular mechanisms of Diamond-Blackfan Anemia (DBA) we have found out that PIM1 interacts with the ribosomal protein RPS19 and cosediments with ribosomes. RPS19 gene is mutated in roughly one fourth of DBA patients, causing a defect in hematopoiesis due to an excess of apoptosis of erythroid precursors. To investigate the possible implication of PIM1 in DBA pathogenesis we have here analyzed the expression of this kinase in cultured cell model systems. These include a stably transfected cell line, inducible for PIM1 overexpression (PIM-REx) and an hematopoietic cell line (K562C), inducible for RPS19 downregulation. We have found that...
Description: 21. ciclo
URI: http://hdl.handle.net/2108/909
Appears in Collections:Tesi di dottorato in scienze matematiche e fisiche

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