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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/780

Title: Interleukin-21 controls inflammatory pathways in IBD
Authors: Pallone, Francesco
Fina, Daniele
Keywords: IBD
cytokines
IL-21
IL-21R
common -chain
matrix metalloproteinases
MIP-3
Issue Date: 3-Feb-2009
Abstract: In both Crohn’s disease (CD) and ulcerative colitis (UC), the major forms of inflammatory bowel diseases (IBD) in humans, the pathologic process consists of an aberrant local immune response to components of the bacterial microflora, due to abnormally strong effector cell activity that is poorly controlled by counter-regulatory mechanisms. There is also evidence that mucosal immune cells actively interact with non-immune cells to promote tissue damage, and that cytokines are essential mediators of this cross-talk. Interleukin-21 (IL-21), the latest member of the common gamma-chain-dependent cytokine family, is a product of activated CD4+ T cells and natural killer T cells. IL-21 is produced in excess in CD tissue, where it helps sustain the ongoing Th1 inflammation. High IL-21 production occurs also in the inflamed colon of most patients with UC, a disease that is not associated with a marked Th1 cell response. This suggests that, in the gut, IL-21 can modulate additional inflammatory ...
Description: 19. ciclo
URI: http://hdl.handle.net/2108/780
Appears in Collections:Tesi di dottorato in medicina

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