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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/774

Title: Studio dell'effetto delle radiazioni non ionizzanti sul processo di maturazione e differenziamento dei granuli cerebellari di ratto neonato: studi in vitro e in vivo
Authors: Calissano, Pietro
Ledda, Mario
Keywords: extremely low frequency electromagnetic field (ELF)
cerebellar granule neurons
ionotropic glutamate receptors
NF-200
newborn rat
Issue Date: 1-Feb-2009
Abstract: The purpose of this study is to examine the effect of Extremely Low Frequency electromagnetic Fields (ELF) on the differentiation of cerebellar granule neurons. These cells represent the main population of the rat cerebellum and is one of the most widespread models for the study of numerous neuronal parameters(Balazs et al.,1988; Gallo et al.,1987; Contestabile 2002). In this research I studied cerebellar granule neurons, in experiments in vitro and in vivo. In the first case I analyzed the effects induced by the exposure to electromagnetic fields on primary cerebellar granule neurons of newborn rats, which were eight days old. In the second case I exposed pregnant rats, for the entire duration of the gestation and I sacrified the newborn rat after eight days of exposure. In both cases the cells exposed to the electromagnet fields of 50 Hz, 1 mT showed one premature reaction to Glutamate toxicity test. Moreover the Patch clamp technique showed an increase of the currents o...
Description: 19. ciclo
URI: http://hdl.handle.net/2108/774
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