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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/735

Title: Transcriptional regulation by thymosin alpha-1 in peripheral blood monuclear cell from HIV positive patients
Authors: Macchi, Beatrice
Minutolo, Antonella
Keywords: thymosin alpha 1
HIV
Issue Date: 8-Jan-2009
Abstract: Thymosin alpha-1 (Tα1) has shown a variety of effects on cells and pathways of the immune system. Tα1 has been shown to exert an immunomodulatory activity towards both T cell and NK maturation. Moreover, Tα1 has been shown to act on effector functions of mature lymphocytes, such as cytokine production and cytotoxic activity. Several clinical studies on patients with infectious or other diseases, have already demonstrated the high tolerability and the absolute safety of Tα1, without side effects at all used doses. In addition, Tα1 has the ability to activate infected dendritic cells through Toll-like receptor signalling, thus influencing the inflammation balance, and increasing the expression of tumour, viral, and major histocompatibility complex (MHC) I antigens. However, information regarding the use of Tα1 in patients with HIV infection is very limited. The principal aim of the experiments performed in the framework of this Ph.D. thesis was to investigate which genes belonging to imm...
Description: 20. ciclo
URI: http://hdl.handle.net/2108/735
Appears in Collections:Tesi di dottorato in medicina

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