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|Title: ||Immune reconstitution in paediatric patients with acquired immunodeficiency|
|Authors: ||Cancrini, Caterina|
|Keywords: ||immune reconstitution|
umbilical cord blood transplantation
T cell receptor
|Issue Date: ||2-Sep-2008 |
|Abstract: ||Background: Immune system plays a crucial role in defending organism from pathogens. However, immunological functions may be severely impaired by a number of disorders including acquired immunodeficiencies, possibly due to infections, chronic diseases, immunosuppressive drugs or surgeon therapies. In order to favour the immune reconstitution of patients with acquired immunodeficiency, various therapeutic treatments are constantly under investigation for both adults and paediatric patients.
Aim of the study: To evaluate immune reconstitution in children with acquired immunodeficiency. Attention was focused on two groups of HIV-1 vertically infected children (the first group subjected to HAART from the third months of life, the second subjected to a simplified treatment) and on a cohort of leukaemia children who underwent Umbilical Cord Blood Transplantation (UCBT).
Materials and Methods: Immune restoration was principally evaluated in terms of lymphoproliferative response and T-cell...|
|Description: ||19. ciclo|
|Appears in Collections:||Tesi di dottorato in medicina|
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