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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/611

Title: Immune reconstitution in paediatric patients with acquired immunodeficiency
Authors: Cancrini, Caterina
Pensieroso, Simone
Keywords: immune reconstitution
acquired immunodeficiency
HIV-1
HAART
umbilical cord blood transplantation
T cell receptor
spectratyping
Issue Date: 2-Sep-2008
Abstract: Background: Immune system plays a crucial role in defending organism from pathogens. However, immunological functions may be severely impaired by a number of disorders including acquired immunodeficiencies, possibly due to infections, chronic diseases, immunosuppressive drugs or surgeon therapies. In order to favour the immune reconstitution of patients with acquired immunodeficiency, various therapeutic treatments are constantly under investigation for both adults and paediatric patients. Aim of the study: To evaluate immune reconstitution in children with acquired immunodeficiency. Attention was focused on two groups of HIV-1 vertically infected children (the first group subjected to HAART from the third months of life, the second subjected to a simplified treatment) and on a cohort of leukaemia children who underwent Umbilical Cord Blood Transplantation (UCBT). Materials and Methods: Immune restoration was principally evaluated in terms of lymphoproliferative response and T-cell...
Description: 19. ciclo
URI: http://hdl.handle.net/2108/611
Appears in Collections:Tesi di dottorato in medicina

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