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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/600

Title: Role of CD1e in microbial glycolipid antigen processing and presentation to unconventional T lymphocytes
Authors: Nisini, Roberto
De Libero, Gennaro
Mariotti, Sabrina
Keywords: enzymatic processing
glycolipid presentation
unconventional T lymphocytes
lysosomal α-mannosydase
acidic compartments
anti-microbial immune response
Issue Date: 1-Sep-2008
Abstract: A subset of T cells recognizes antigenic complexes formed by CD1 molecules (CD1a, b, c or d) associated with self or microbial glycolipid antigens, which in some instances become immunogenic only after being processed. CD1e is the fifth member of the human CD1 family and is the only isoform whose function was unknown. In immature dendritic cell (DC) CD1e resides in Golgi compartments and upon DC maturation it reaches acidic late endosomes/lysosomes where it is cleaved and accumulates in a stable soluble form. Remarkably, unlike the other CD1 molecules, CD1e never transits through the cell surface, a characteristic that excludes its direct interaction with T cells. Here, it’s demonstrated that the mycobacterial glicolipid antigen hexamannosylated-phosphatidyl-myo-inositol (PIM6) stimulates CD1b-restricted specific T cells only after digestion of the four terminal mannoses by lysosomal α-mannosidase, and that lysosomal CD1e is required for this processing. These data show tha...
Description: 19. ciclo
URI: http://hdl.handle.net/2108/600
Appears in Collections:Tesi di dottorato in medicina

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