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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/595

Title: Identification of cellular kinases responsible for Hepatitis C Virus NS5A hyperphosphorylation
Authors: Cesareni, Gianni
Santoro, Gabriella
Quintavalle, Manuela
Issue Date: 29-Aug-2008
Abstract: Hepatitis C virus (HCV) has been the subject of intensive studies for nearly two decades. Nevertheless, some aspect of the virus life cycle are still a mystery. The HCV Nonstructural protein 5A (NS5A) has been shown to be a modulator of cellular processes possibly required for the establishment of viral persistence. NS5A is heavily phosphorylated, and a switch between a basally phosphorylated form of NS5A (p56) and a hyperphosphorylated form of NS5A (p58) seems to play a pivotal role in regulating HCV replication. Efficient replication of HCV subgenomic RNA in cell culture requires the introduction of adaptive mutations. Some of the most effective adaptive mutations occur at the serine residues that have been shown to be implicated in NS5A hyperphosphorylation and adaptive mutations at these sites result in a significant reduction of NS5A hyperphosphorylation (p58). After screening of a panel of kinase inhibitors, we selected three compounds which inhibited NS5A phosphory...
Description: 19. ciclo
URI: http://hdl.handle.net/2108/595
Appears in Collections:Tesi di dottorato in scienze matematiche e fisiche

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