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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/584

Title: Valutazione dell’accumulo corporeo totale di ferro in pazienti β-talassemici
Authors: Federici, Giorgio
Andreani, Marco
Bertucci, Pierfrancesco
Keywords: β-talassemia maior
sovraccarico di ferro
concentrazione epatica su un campione di biopsia epatica (LIC)
spettroscopia di assorbimento atomico in fiamma (FAAS)
mineralizzazione del campione bioptico
terapia ferro-chelante
trapianto di midollo osseo
Issue Date: 28-Aug-2008
Abstract: β-Thalassemia represents a common single-gene disorder characterised by a defective production of the globin β-chains, which form the haemoglobin molecule. Defective haemoglobin generates a chronic anaemic state in affected patients during the first decade of life, which leds to a progressive accumulation of iron in body tissues, due to recurrent emotransfusional therapy. Overload of iron in endocrine glands, myocardial tissue and liver represents the most evident complication in patients affected by β-thalassemia maior. Measurement of the iron concentration in a liver-biopsy specimen (LIC) by flame atomic absorption spectrophotometry (FAAS) is the reference method for assessing body iron stores in β-thalassemic patients. FAAS offers a great sensitivity for trace metal analysis and determination of liver iron concentration was performed using a Perkin Elmer Analyst 800, equipped with an air-acetylene flame burner head. A pre-analytic phase was required for essication and mineralization...
Description: 19. ciclo
URI: http://hdl.handle.net/2108/584
Appears in Collections:Tesi di dottorato in medicina

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