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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/571

Title: Bordetella pertussis and human monocyte-derived dendritic cells: a tool to identify an evading mechanism
Authors: Ausiello, Clara M.
Spensieri, Fabiana
Keywords: Bordetella pertussis monocyte-derived dendritic cells interleukin (IL)-12 interleukin (IL)-23 adenylate cyclase toxin cAMP interferon regulatory factorsimmunoevasion T helper 1
Issue Date: 25-Aug-2008
Abstract: Bordetella pertussis is the etiologic agent of pertussis or “wooping cough”, an highly, contagious and acute respiratory infection. B. pertussis is a strict human pathogen and transmission of disease occurs via respiratory droplets. B. pertussis posses different virulence factors classified in two categories: “adhesins” and “toxins”. Virulence factors facilitate the bacteria'’s ability to adhere to respiratory cells and produce local and sistemic alterations in cell pathophysiology which contribute to microrganism replication and its capacity to evade host immune response. Adenylate cyclase toxin (ACT) is the B. pertussis factors which induces cell intoxication via cyclic AMP (cAMP) leading to inhibition of several immune functions allowing persistence of B. pertussis in the host and progression of infection. The mechanism underlying protection to B. pertussis infection is still a matter of debate. A central role in immunity is played by dendritic cells (DCs). DCs represent th...
Description: 19. ciclo
URI: http://hdl.handle.net/2108/571
Appears in Collections:Tesi di dottorato in medicina

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