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|Title: ||Ruolo delle alterazioni mitocondriali nel processo di morte cellulare in patologie neurodegenerative|
|Authors: ||Piacentini, Mauro|
corea di Huntington
|Issue Date: ||28-Jul-2008 |
|Abstract: ||Apoptosis and autophagy are cell death pathways characterised by great modification of the cell structure, among which morphological and functional alterations of mitochondria. The loss of mitochondrial membrane potential (MMP) (Reed and Kroemer, 2000) could be considered both an early event towards apoptosis or a signal associated with autophagy of the organelles (Rodriguez-Enriquez et al., 2004).
We previously observed that TG2 (Transglutaminase 2) over-expressing cells showed mitochondria that were greatly modified with respect to both their ultrastructure and physiology (Piacentini et al., 2002), with a constitutive hyperpolarization of the inner membrane. Even if TG2 expression is increased during apoptosis, the exact role of the enzyme in the cascade of events leading to cell death remain to be clarified. The first part of this thesis investigated, at a molecular level, the extension of TG2- mitochondrial modification as well as the possible interaction between TG2 and the prote...|
|Description: ||19. ciclo|
|Appears in Collections:||Tesi di dottorato in scienze matematiche e fisiche|
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