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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/551

Title: Antiviral activity of Vgamma9Vdelta2 T cells: a possible target for immunotherapy
Other Titles: Attività antivirale dei linfociti T Vgamma9Vdelta2: un nuovo bersaglio per strategie immunoterapeutiche
Authors: Colizzi, Vittorio
Agrati, Chiara
Keywords: innate immunity
viral infections
immunotherapy
alpha-defensin
gamma-interferon
Issue Date: 14-Jul-2008
Abstract: Vgamma9Vdelta2 T cells represent a key subset in innate immunity. They represent 1-5% of the circulating T cells and can be massively activated by non peptidic compounds generated by metabolic pathways. The activation of Vgamma9Vdelta2 T cells results in killing of infected cells and in fast release of soluble factors with direct antimicrobial properties, as well as immunomodulatory activity. The main aim of this work was to define the antiviral mechanisms activity exploited by Vgamma9Vdelta2 T cells in order to evaluate their possible use as target for new immunotherapy. The antiviral activity of Vgamma9Vdelta2 T cells against SARS-CoV and HCV infections was evaluated. Health care workers who survived SARS-CoV infection showed a selective expansion of effector/memory Vgamma9Vdelta2 T cells which was associated with a higher anti SARS-CoV IgG titers, suggesting a possible involvement of Vgamma9Vdelta2 T cells in SARS immunosurveillance. In addition, in vitro experiments demonstrated ...
Description: 20. ciclo
URI: http://hdl.handle.net/2108/551
Appears in Collections:Tesi di dottorato in scienze matematiche e fisiche

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