DSpace - Tor Vergata: Item 2108/521

Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/521

Title:	Caratterizzazione clinica, metabolica e infiammatoria di una popolazione di coronaropatici senza apparenti disturbi del metabolismo glicidico: studio MIDIAB
Authors:	Lauro, Renato Rizza, Stefano
Keywords:	adiponectin TNF-alfa diabete coronaropatia pioglitazone
Issue Date:	3-Jun-2008
Abstract:	Objective: patients with a previous Myocardial Infarction (MI) and Type 2 diabetes (DM) have the highest risk for cardiovascular mortality, but T2DM is often undiagnosed. We tried to identify which among inflammatory and metabolic markers is the best predictor of T2DM in our population. Methods and Results: glucose tolerance status in patients with a previous MI and no diagnosis of diabetes was correlated to severity of coronary artery disease and pro- and anti-inflammatory markers (high sensitivity C-Reactive Protein, TNF-alfa, Adiponectin). In non diabetic CAD patients, upon OGTT, we observed that 20% of the patients were affected by T2DM, 37% by impaired glucose tolerance (IGT), and only the 43% were really normoglycemic (NGT). The number of disease affected vessels was correlated to 2h-post load glucose value (Spearman’s ñ=0.3, p<0.01). Interestingly, we found that while at univariate analysis the 2h-post load glucose level was positively correlated with TNF-alfa (r =0.25...
Description:	19. ciclo
URI:	http://hdl.handle.net/2108/521
Appears in Collections:	Tesi di dottorato in medicina

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