DSpace - Tor Vergata: Item 2108/506

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Title:	Sox2 conditional deletion in germ cells: a potential role in gametogenesis
Authors:	Dolci, Susanna Gori, Manuele
Keywords:	Sox2 Oct4 PGCs pro-spermatogonia spermatogonial stem cells Cre recombinase
Issue Date:	28-May-2008
Abstract:	During mammalian pre-implantation development pluripotent cells are established within the inner cell mass (ICM). These pluripotent cells contribute to all the somatic cell lineages and establish the germ line, the only cell lineage to be transmitted to the next generation. The molecular mechanisms leading to germ cell specification have not been elucidated, but some genes that are critical for pluripotent cells and during pre-implantation development are subsequently restricted to the germ lineage. Among these genes Sox2 has been shown to be specifically expressed in the ICM, in neural stem cells and in primordial germ cells (PGCs). Sox2 deletion is lethal very early during embryogenesis, and null blastocysts do not develop correctly at implantation. To understand the timing of Sox2 expression in germ cells, we first performed β-galactosidase histochemistry on whole-mount embryos, including gonads, at various developmental stages by using Sox2-βgeo knock-in mice. By Northern...
Description:	20. ciclo
URI:	http://hdl.handle.net/2108/506
Appears in Collections:	Tesi di dottorato in medicina

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