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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/448

Title: The Antigen 85B of mycobacterium tuberculosis: friend or foe in vaccination against tubercolosis?
Authors: Cassone, Antonio
Palma, Carla
Keywords: tuberculosis
vaccine
Ag85B antigen
T cells
B cells
antibodies
cytokines
Issue Date: 18-Apr-2008
Abstract: Mycobacterium tuberculosis (MTB) ability to escape from host immune system is central in tuberculosis (TB) pathology, and raises a major issue to develop effective TB vaccines. We found that anti-TB Th1 response, essential in controlling the acute phase of infection, is highly dynamic and greatly affected by mycobacterial antigen pressure. In our study, we used Ag85B, a recognized immunodominant constituent of the mycobacterial cell wall, as primary DNA vaccine and/or as protein booster or primary stimulant. The Ag85B-encoding DNA (DNA-85B) vaccine was protective in mice but this protection vanished when the protein Ag85B, but not successive DNA- 85B injections, was used as a booster. The loss of protection was associated with the expansion of a population of CD4+ T cells, highly proliferating and secreting a huge amount of IFN-γ in response to the exogenous Ag85B protein but incapable to recognize Ag85B-expression on MTB-infected macrophages. The balance between IFN-γ needed...
Description: 19. ciclo
URI: http://hdl.handle.net/2108/448
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