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|Title: ||Nerve growth factor (NGF) in the experimental autoimmune Encephalomyelitis|
|Authors: ||Cesareni, Giovanni|
|Issue Date: ||10-Mar-2006 |
|Abstract: ||ABSTRACT BREVE(in inglese)
Multiple sclerosis (MS) stands out among neurological diseases by virtue of its frequency, chronicity, and tendency to attack young adults. The pathological hallmark of MS is the presenceof multiple lesions (plaques) characterized by various degrees of inflammation, demyelination, and gliosis in the central nervous system (CNS).
Experimental allergic encephalomyelitis (EAE) has been extensevely studied and widely used as animal model of MS.
The cerebrospinal fluid (CSF) of patients affected by MS and rodents with EAE show elevated levels of Nerve Growth Factor (NGF). This increase correlates with the course of the disease and show a maximum in corrispondence of the pick of the pathology.
NGF is the best characterized member of a family of neurotrophic factors and is crucial for development of the CNS, promoting neuronal repair in a number of CNS insults. Moreover, during EAE, an upregulation of the levels of both the protein and the mRNA for NGF ha...|
|Appears in Collections:||Tesi di dottorato in scienze matematiche e fisiche|
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