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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/224

Title: Bacillus Calmette-Guerin (BCG) and environmental mycobacteria divert Dendritic Cell functions interfering with the differentiation of precursors into competent APCs
Authors: Doria, Gino
Martino, Angelo
Keywords: BCG
Tubercolosi
cellule dendritiche
monociti
Issue Date: 7-Mar-2006
Abstract: Thesis of PhD of Immunology 2004 Bacillus Calmette-Guerin (BCG) and environmental mycobacteria divert Dendritic Cell functions interfering with the differentiation of precursors into competent APCs Human monocytes can differentiate into dendritic cells (DCs) according to the nature of environmental signals. We tested here whether the infection with the live tuberculosis vaccine Bacillus Calmette-Guerin (BCG), that is known to be limited in preventing pulmonary tuberculosis, modulate monocytes and DCs differentiation. We found that monocytes infected with BCG differentiate into CD1a- DCs (BCG-DCs) in the presence of GM-CSF and IL-4 and acquired a mature phenotype in the absence of maturation stimuli. In addition, BCG-DCs produced pro-inflammatory cytokines (TNF-a, IL-1b, and IL-6) and IL-10 but not IL-12. BCG-DCs were able to stimulate allogeneic T lymphocytes to a similar degree as DCs generated in the absence of infection. However, BCG-DCs induced IL-4 production when co-cultur...
URI: http://hdl.handle.net/2108/224
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