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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/223

Title: Cellule dendritiche e patogenesi indotta da HIV : ruolo svolto nell'induzione di citochine th2-like
Authors: Doria, Gino
Sacchi, Alessandra
Keywords: HIV
MoDC
CD1a
Th1/Th2
Issue Date: 7-Mar-2006
Abstract: ABSTRACT Dendritic cells (DC) are professional antigen presenting cells that play a central role in the induction and regulation of immune response towards microbes. In the present study, the capacity of monocytes isolated from HIV+ Caucasian and African patients to differentiate into fully mature DC (MoDC) was evaluated. Moreover the ability of MoDC to induce an HIV specific immune response was investigated. We show that monocytes isolated from HIV infected patients at different stage of the disease are able to differentiate into MoDC in the presence of GM-CSF and IL-4. However, MoDC from 30% of Caucasian and 45% of African patients did not express CD1a molecule on their membrane giving rise to an homogeneus population CD11c+ CD1a-. We observed that the presence of the CD11c+ CD1a- population correlates with the higher percentage of HIV-specific CD4+ T cells producing IL-4. Moreover, in contrast to CD11c+ CD1a+, the CD11c+ CD1a- MoDC produce IL-10 and not IL-12 and when cultured w...
URI: http://hdl.handle.net/2108/223
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