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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/188

Title: Post-translational modifications regulate p73 functions
Authors: Melino, Gerry
Levrero, Massimo
Merlo, Paola
Issue Date: 20-Dec-2005
Abstract: TP53 is a tumor suppressor gene whose product is involved in cellular growth inhibition, apoptosis and senescence. Two new classes of proteins recently discovered, p63 and p73 proteins, share with p53 a high structural homology and overlapping yet specific functions. p63 and p73 can be expressed as TA forms that have the Transcriptional Activation Domain, behave as p53-like proteins and show variability at the C-terminus due to alternative splicing. Indeed p63 and p73 can be also expressed from an alternative promoter or by N-terminal alternative splicing and the products are ΔNp73 or ΔTAp73 forms that are truncated at the N-teminus and act as dominant negative proteins of the other p53 family members. Although p53 family proteins share the main functional domains and activate the transcription of a subset of common genes, unlike p53, p73 and p63 do not have clear features of tumor suppressors. Actually their activity is more complex and still not well defined. The enti...
Description: 16. ciclo
URI: http://hdl.handle.net/2108/188
Appears in Collections:Tesi di dottorato in medicina

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Tesi Merlo 4.pdfTesto della tesi3884KbAdobe PDFView/Open
Tesi Merlo 3.pdfAbstract e indice78KbAdobe PDFView/Open
Tesi Merlo 1.pdfFrontespizio23KbAdobe PDFView/Open

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