DSpace - Tor Vergata: Item 2108/188

Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/188

Title:	Post-translational modifications regulate p73 functions
Authors:	Melino, Gerry Levrero, Massimo Merlo, Paola
Issue Date:	20-Dec-2005
Abstract:	TP53 is a tumor suppressor gene whose product is involved in cellular growth inhibition, apoptosis and senescence. Two new classes of proteins recently discovered, p63 and p73 proteins, share with p53 a high structural homology and overlapping yet specific functions. p63 and p73 can be expressed as TA forms that have the Transcriptional Activation Domain, behave as p53-like proteins and show variability at the C-terminus due to alternative splicing. Indeed p63 and p73 can be also expressed from an alternative promoter or by N-terminal alternative splicing and the products are ΔNp73 or ΔTAp73 forms that are truncated at the N-teminus and act as dominant negative proteins of the other p53 family members. Although p53 family proteins share the main functional domains and activate the transcription of a subset of common genes, unlike p53, p73 and p63 do not have clear features of tumor suppressors. Actually their activity is more complex and still not well defined. The enti...
Description:	16. ciclo
URI:	http://hdl.handle.net/2108/188
Appears in Collections:	Tesi di dottorato in medicina

Files in This Item:

File	Description	Size	Format
Tesi Merlo 4.pdf	Testo della tesi	3884Kb	Adobe PDF	View/Open
Tesi Merlo 3.pdf	Abstract e indice	78Kb	Adobe PDF	View/Open
Tesi Merlo 1.pdf	Frontespizio	23Kb	Adobe PDF	View/Open