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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/1443

Title: Structural plasticity of the adult cerebellar climbing fibres: an in vivo study on the role of the growth-associated protein 43
Authors: Strata, Piergiorgio
Ciriolo, Maria Rosa
Grasselli, Giorgio
Keywords: cerebellum
climbing fibre
GAP-43
plasticity
Issue Date: 6-Sep-2010
Abstract: The growth-associated protein GAP-43 has a pivotal role in axonal growth and guidance during development. Towards the end of postnatal development its expression dramatically declines in most brain regions with few exceptions, such as cerebellar cortex and inferior olive (IO). When experimentally over-expressed in murine CNS in vivo, it is able to induce axonal sprouting, moreover it is up-regulated in conditions known to induce a structural remodelling of neuronal connectivity, such as injuries to the CNS and neurodegenerative disorders. However the reason why high expression is maintained through adulthood only in some regions in the adult brain has never been clarified. Taking advantage of lentiviral vectors and shRNAs to induce an efficient and stable gene silencing specifically in the IO, we chose to investigate GAP-43 role in axonal remodelling of the adult CFs, since they originate from one of the nuclei which retain GAP-43 high expression levels, they are conveniently arranged...
Description: 22. ciclo
URI: http://hdl.handle.net/2108/1443
Appears in Collections:Tesi di dottorato in scienze matematiche e fisiche

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