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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/1430

Title: Thrombophilia, systemic inflammation and prevention of cardiovascular disease in children and adolescents with HIV infection
Authors: Franco, Elisabetta
Pontrelli, Giuseppe
Keywords: HIV
atherosclerosis
children
inflammation
thrombophilia
Issue Date: 21-Aug-2010
Abstract: Atherosclerosis begins early in the lifetime and, as for other cardiovascular diseases associated with thrombosis, appears more relevant and anticipated in HIV-infected patients after combination antiretroviral therapy (cART) has reduced AIDS-related diseases and has improved survival. Systemic chronic inflammation, a condition associated with HIV, could have a role in determining anticipated cardiovascular diseases since it is a risk factor for atherosclerosis. The association between viral replication, inflammation and coagulation abnormalities in a cohort of HIV-infected children and adolescents was investigated as aim of this research project. In a first part of the research, prevalence of metabolic syndrome (hyper-cholesterolemia, hyper-trigliceridemia, hyper-glicemia), well characterized in adults on antiretroviral treatment, was studied in the cohort of children and adolescents. In the second part, assays on thrombophilia (protein S, protein C anticoagulant and antithrombin a...
Description: 22. ciclo
URI: http://hdl.handle.net/2108/1430
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