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Title:	Thrombophilia, systemic inflammation and prevention of cardiovascular disease in children and adolescents with HIV infection
Authors:	Franco, Elisabetta Pontrelli, Giuseppe
Keywords:	HIV atherosclerosis children inflammation thrombophilia
Issue Date:	21-Aug-2010
Abstract:	Atherosclerosis begins early in the lifetime and, as for other cardiovascular diseases associated with thrombosis, appears more relevant and anticipated in HIV-infected patients after combination antiretroviral therapy (cART) has reduced AIDS-related diseases and has improved survival. Systemic chronic inflammation, a condition associated with HIV, could have a role in determining anticipated cardiovascular diseases since it is a risk factor for atherosclerosis. The association between viral replication, inflammation and coagulation abnormalities in a cohort of HIV-infected children and adolescents was investigated as aim of this research project. In a first part of the research, prevalence of metabolic syndrome (hyper-cholesterolemia, hyper-trigliceridemia, hyper-glicemia), well characterized in adults on antiretroviral treatment, was studied in the cohort of children and adolescents. In the second part, assays on thrombophilia (protein S, protein C anticoagulant and antithrombin a...
Description:	22. ciclo
URI:	http://hdl.handle.net/2108/1430
Appears in Collections:	Tesi di dottorato in medicina

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