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|Title: ||Thrombophilia, systemic inflammation and prevention of cardiovascular disease in children and adolescents with HIV infection|
|Authors: ||Franco, Elisabetta|
|Issue Date: ||21-Aug-2010 |
|Abstract: ||Atherosclerosis begins early in the lifetime and, as for other cardiovascular diseases associated with thrombosis, appears more relevant and anticipated in HIV-infected patients after combination antiretroviral therapy (cART) has reduced AIDS-related diseases and has improved survival.
Systemic chronic inflammation, a condition associated with HIV, could have a role in determining anticipated cardiovascular diseases since it is a risk factor for atherosclerosis. The association between viral replication, inflammation and coagulation abnormalities in a cohort of HIV-infected children and adolescents was investigated as aim of this research project.
In a first part of the research, prevalence of metabolic syndrome (hyper-cholesterolemia, hyper-trigliceridemia, hyper-glicemia), well characterized in adults on antiretroviral treatment, was studied in the cohort of children and adolescents. In the second part, assays on thrombophilia (protein S, protein C anticoagulant and antithrombin a...|
|Description: ||22. ciclo|
|Appears in Collections:||Tesi di dottorato in medicina|
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