DSpace - Tor Vergata: Item 2108/1420

Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/1420

Title:	Survey regarding the use of adalimumab as maintenance therapy in Crohn’s disease in England and Ireland
Authors:	Angelico, Mario Subrata, Ghosh Iacucci, Marietta
Keywords:	adalimumab anti-TNF Crohn’s disease survey response/remission
Issue Date:	9-Aug-2010
Abstract:	Introduction: Adalimumab is effective in inducing and maintaining response/remission in patients with Crohn’s Disease (CD) either naive to biological therapies or following secondary failure of infliximab. Aim: To present the first ‘real-life’ survey data from England and Ireland on the use of adalimumab. Method: A retrospective audit conducted by a web-based questionnaire in England/Ireland. Results: We analysed data on 61 patients (35 female) with a median age of 33 years (range 17-71) with average follow-up of 8 months. Maximal maintenance dose was 40mg every other week in 84% of patients, 40mg weekly in 13% and 80mg weekly in 3%. Maintenance adalimumab achieved remission in 57% of patients. The ongoing response rate was 83.6%. An additional 8% had a secondary loss of response after average of 8.4 months (range 2-17). 23% had adverse effects, of which local pain 29%, infection 36%, headaches 14%, leucopenia (on AZA) 7%, a painful rash 7%, serum-sickness type reaction 7%. Ad...
URI:	http://hdl.handle.net/2108/1420
Appears in Collections:	Tesi di dottorato in medicina

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