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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/1416

Title: Transcriptional and post-transcriptional mechanisms control meiotic entry in mouse germ cells
Authors: Dolci, Susanna
Barrios Abraham, Florencia
Keywords: Nanos2
spermatogonia
Issue Date: 9-Aug-2010
Abstract: In the mouse, three genes homologous to the Drosophila Nanos (Nos) gene have been identified. Deletion of one of the Nanos genes, Nanos2, results in male sterility, due to germ cell loss during the fetal life. Before apoptosis, Nanos2 null gonocytes enter meiosis, suggesting that Nanos2 functions as a meiotic repressor. Here we show that Nanos2 is continuously expressed in male germ cells from fetal gonocytes to postnatal spermatogonial stem cells. We observed that the pro-meiotic factor AtRA, an analog of retinoic acid (RA), down-regulates Nanos2 levels both in fetal and postnatal gonocytes while promoting meiosis. Interestingly, FGF9, a growth factor crucial for sex differentiation and for survival of fetal gonocytes, upregulates Nanos2 levels in both male and female primordial germ cells (PGCs) and in premeiotic spermatogonia. This effect was paralleled by an impairment of meiotic entry, suggesting that FGF9 acts as an inhibitor of meiosis through the upregulation of NANOS2. We foun...
Description: 22. ciclo
URI: http://hdl.handle.net/2108/1416
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