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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/1374

Title: HLA DQ and onchocerciasis in Ecuador: interactions between genetics and environment in an endemic infection
Authors: De Stefano, Gian Franco
De Angelis, Flavio
Keywords: human leukocyte antigens
high resolution molecular typing
onchocerciasis
north-western Ecuador
Cayapas
Afroecuadorians
association study
SNP
Issue Date: 3-Aug-2010
Abstract: Due to its long exposure to infectious diseases, the human genome tends to be gradually modified through natural selection, especially at level of the Human Leukocyte Antigen (HLA) complex. The aim of this study is to explore HLA DQ variability in two populations (Cayapas Indians and Afro-Ecuadorians) living near one another in the same rain forest along the Cayapa river (northwestern Ecuador) and exposed to the same environmental stress, i.e. infection by O. volvulus. Two HLA class II loci (HLA DQB1 and HLA DQA1) of 211 unrelated individuals have been analyzed. HLA high-resolution molecular typing was performed by three different techniques: Sequence Specific Oligonucleotides hybridization (SSO), Sequence Specific Primer amplification (SSP) and direct Sequencing (Sequence Based Typing, SBT). The comparison between cases and controls in both populations shows the key role of several HLA DQA1 alleles in susceptibility and protection from O. volvulus infection. A potential protective all...
Description: 22. ciclo
URI: http://hdl.handle.net/2108/1374
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