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|Title: ||Intracellular and surface redox systems in human platelets|
|Authors: ||Avigliano, Luciana|
|Keywords: ||human platelets|
|Issue Date: ||1-Mar-2010 |
|Abstract: ||Redox balance is important for platelet physiology, indeed it is crucial for blood coagulation and thrombosis. This thesis will give an update on intracellular and plasma membrane systems involved on redox homeostasis in human platelets, with particular regard to vitamin C and plasma membrane NAD(P)H oxidases.
The redox balance is linked to the presence of intracellular antioxidants; in particular, vitamin C appears to be a key modulator of platelet oxidative state, since these cells physiologically accumulate ascorbic acid. Here, we showed, for the first time, that platelets could compensate for fluctuations in ascorbate levels by modulating the expression of the Na+-dependent transporter SVCT2 at translational level. Moreover, we showed that changes in intracellular ascorbic acid content had physiological relevance, since they modulate the surface sulfhydryl content and the thrombus viscoelastic properties.
Intracellular reducing equivalents can be propagated to the plasma membran...|
|Description: ||21. ciclo|
|Appears in Collections:||Tesi di dottorato in medicina|
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