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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/1179

Title: Neuronal plasticity of hippocampal and cortical circuitry modulates the formation and extinction of remote adversive memories
Other Titles: La plasticità neuronale dei circuiti ippocampali e corticali modula la formazione e l’estinzione delle memorie remote avversive
Authors: Mercuri, Nicola Biagio
Ammassari-Teule, Martine
Vetere, Gisella
Keywords: memory
hippocampus
prefrontal cortex
dendritic spines
consolidation
extinction
structural plasticity
synaptic plasticity
Issue Date: 15-Jan-2010
Abstract: It is generally believed that in order to enable long-term episodic memory, the information is temporarily stored in the hippocampus where it remains vulnerable to interference. Via a slow read-out process, the information is transferred into other brain structures where the memory is established and no longer vulnerable to interference. This slow read-out is termed consolidation (Mueller and Pilzecker, 1900). The mechanisms by which memories can be acquired and consolidated in the mammalian brain are assumed to involve modifications in structural plasticity (Cajal, 1891). The main goal of this work is to discover the morphological modification requested in memory formation and extinction. In study I we shown that plastic changes (i.e. dendritic spine density increase) immediately develop in CA1 field of the hippocampus after a training in the contextual fear conditioning. These modifications are only transient because they disappear 36 days later, while an inverse pattern of spi...
Description: 22. ciclo
URI: http://hdl.handle.net/2108/1179
Appears in Collections:Tesi di dottorato in medicina

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