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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/1135

Title: La mutazione di tipo A della nucleofosmina nella diagnosi e nel follow-up della leucemia mieloide acuta
Authors: Lo Coco, Francesco
Ottone, Tiziana
Keywords: AML
NPM
RT-ASO-PCR
nested-ASO-PCR
capillary electrophoresis
Issue Date: 22-Sep-2009
Abstract: Acute myeloid leukaemias (AML), which account for about 80% of the acute leukaemias in adult, represent a phenotypically and genetically heterogeneous group of clonal haematopoietic diseases in which, failure to differentiate and over proliferation in the stem cell/progenitor compartment, result in accumulation of non-functional myeloblasts. Nucleophosmin-1 (NPM1) mutations is the most frequent gene alteration in AML (30%), and are particularly frequent in AML with normal karyotype (AML-NK) (60%). These alterations have been shown to carry prognostic significance because they seem to identify patients with better response to chemotherapy. As a consequence, the analysis of NPM1 mutational status is now recommended for inclusion in the genetic routine characterization of AML (Gorello P. et al., Leukemia 2006; Ammatuna E. et al., Clin Chem 2005; Nelida I.N. et al., Leukemia 2005; Scholl S. et al., Leuk Res 2007; Lin LI et al., Leukemia 2006). Finally, given their high prevalence and sta...
Description: 20. ciclo
URI: http://hdl.handle.net/2108/1135
Appears in Collections:Tesi di dottorato in medicina

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