DSpace - Tor Vergata: Item 2108/1115

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Title:	Riduzione della risposta monocitica al CD40L in corso di sepsi
Other Titles:	Downregulation of CD40L response in monocytes from septic patients
Authors:	Bergamini, Alberto Natoli, Silvia
Keywords:	sepsi immunoparalisi interazioni CD40/CD40L macrofagi
Issue Date:	4-Sep-2009
Abstract:	A defective adaptive immune response has been suggested to contribute to septic immunosuppression. Here, the response of monocytes to CD40-ligand (CD40L) has been analyzed in patients with Gram-negative sepsis. As compared to cells from controls, monocytes from septic patients showed significantly reduced production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-12 and were unable to acquire high levels of CD80 and CD86 molecules. These alterations were observed at the onset of sepsis and persisted at day 7. However, the ability of monocytes to respond to CD40L stimulation was partially, but significantly, restored in patients who recovered from sepsis. In addition, costimulation of autologous CD4+ T lymphocytes by CD40L-activated monocytes from septic patients failed to induce cell proliferation and interferon (IFNγ) production. Finally, the ability of CD40L to rescue monocytes from apoptosis was severely impaired. We conclude that downregulation of CD40L response may b...
Description:	21. ciclo
URI:	http://hdl.handle.net/2108/1115
Appears in Collections:	Tesi di dottorato in medicina

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