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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/1082

Title: Immunità innata e tubercolosi: identificazione di ligandi molecolari coinvolti nella risposta antitubercolare e generazione di liposomi contenenti lipidi bioattivi ad attività immunomodulante
Authors: Fraziano, Maurizio
Greco, Emanuela
Keywords: tubercolosi
mycobacterium tuberculosis
immunità innata
interazione ospite-patogeno
sequenze oligodeossinucleotidiche CpG
acido lisofosfatidico
sfingosina 1-fosfato
acido fosfatidico
Issue Date: 2-Sep-2009
Abstract: Tuberculosis (TB) is a worldwide infection disease, due to a single pathogen infection, which is estimated to kill over 2 million people annually. The causative agent of TB is Mycobacterium tuberculosis (MTB), an intracellular pathogen which infects human host and interferes with host antimicrobial pathways to allow intracellular survival, inhibiting Phospholipase D (PLD) dependent Phosphatidic Acid (PA) generation. The present study shows a novel role of synthetic oligodeoxynucleotides containing unmethylated CpG dinucleotides (CpG ODN), Lysophosphatidic Acid (LPA) and Sphingosine 1-phosphate (S1P) in the activation of antimicrobial immune response by innate immune cells, such as human monocytes/macrophages and type II human alveolar epithelial cells alveolar. In this context, we found that CpG, LPA and S1P stimulation i) induce Ca++-dependent PLD activation, ii) promote PLD-dependent phagolysosome maturation, and iii) enhance a PLD dependent intracellular mycobacterial killing. These...
Description: 21. ciclo
URI: http://hdl.handle.net/2108/1082
Appears in Collections:Tesi di dottorato in scienze matematiche e fisiche

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