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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/1029

Title: Chronic and acute alcohol exposure prevents monocyte-derived dendritic cells from maturing in response to microbial stimuli
Authors: Riganò, Rachele
Buttari, Brigitta
Keywords: alcoholics
dendritic cells
cellule dendritiche
costimulatory molecules
molecole costimolatorie
Issue Date: 25-Aug-2009
Abstract: Research demonstrating alcohol's adverse effects on functions of the immune system supports clinical evidence of an increased incidence of infectious diseases, such as pneumoniae, tuberculosis and hepatitis C, as well as a greater susceptibility to cancer in humans chronically abusing alcohol. While the association of alcohol abuse with increased deaths from infections was made over 75 years ago, only in the past 15 years has serious investigative efforts been made to understand the role of alcoholic exposure on immune dysfunction. Among the many alcoholics whose socioeconomic status is poor, overcrowded living conditions and limited access to health care may increase the likelihood of contracting and spreading disease. In addition, many alcoholics suffer from malnutrition and liver disease, conditions that may themselves compromise the immune system's capacity to resist infection. Evidence from human and animal studies in vivo as well as from experiments in vitro suggests that alcohol...
Description: 21. ciclo
URI: http://hdl.handle.net/2108/1029
Appears in Collections:Tesi di dottorato in medicina

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