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Please use this identifier to cite or link to this item: http://hdl.handle.net/2108/1022

Title: IL-10 mediated immunological tolerance: preclinical and clinical studies
Authors: Bacchetta, Rosa
Roncarolo, Maria Grazia
Serafini, Giorgia
Keywords: thalassemia
stem cell transplantation
immunological tolerance
mixed chimerism
Issue Date: 24-Aug-2009
Abstract: Thalassemia Major can be cured with allogeneic hematopoietic stem-cell transplantation (HSCT). Persistent mixed chimerism (PMC) develops in around 10% of transplanted thalassemic patients, but the biological mechanisms underlying this phenomenon are poorly understood. IL-10 is an immunomodulant cytokine that plays a central role in controlling inflammation, down-regulating immune responses, and inducing immunological tolerance. Detection of high levels of IL-10, produced by PBMCs of patients with PMC, in comparison to those of patients with complete donor chimerism (CC) or normal donors (ND), prompted us to characterize the T cell repertoire in a thalassemic patient with long-term tolerance following HSCT. From the peripheral blood of the PMC patient, T cell clones of both host and donor origin could be isolated. Together with effector T cell clones, reactive against host or donor alloantigens, we identified regulatory T cell clones, with a cytokine secretion profile typical of type 1 ...
Description: 21. ciclo
URI: http://hdl.handle.net/2108/1022
Appears in Collections:Tesi di dottorato in medicina

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